Observational research with electronic health record (EHR) data is conducted to study associations, trends, and outcomes in healthcare settings. Large-scale, real-world insights may be obtained when the research is conducted though a federated network of healthcare institutions and data sources or a centralized repository containing harmonized, multi-institutional data. Compared to clinical trials, observational studies are generally less costly in terms of time, personnel, and financial resources. When rigorous research practices are applied, the potential effects of non-randomization and systemic bias can be mitigated.
See the CODIAC for Health chapter on Observational Research with EHR Data for more information.